(Phytochemicals in) Foods to Prevent and Treat Cancers - Ovarian Cancer

The ovaries are oval shaped ovum-producing reproductive organ in part of a woman's reproductive system connected to the fallopian tubes and attached to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovary takes turn to release an egg every month.

Ovarian cancer is defined as a condition of abnormal cells growth of ovarian cells as that have become cancerous. It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.

Types
Ovarian cancer can be divided to the types below
A. Epithelial ovarian Cancer
Epithelial ovarian tumor also known as Surface epithelial-stromal tumor, as the name, it is a result of the cells on the surface of the ovary have become cancerous. Epithelial ovarian tumor is the most common form of ovarian cancer accounted for over 90% of ovarian cancer of all cases, including serous tumor, endometrioid tumor and mucinous cystadenocarcinoma.

B. Germ cell ovarian cancer

Germ cell ovarian tumor is a censer of the egg producing cells within the ovary and can be cancerous or non-cancerous tumors. It tends to occur in children and teens as a result of birth defects resulting from errors during development of the embryo.

C. Sex cord stromal ovarian cancer
Sex cord stromal ovarian tumor is a cancer of the tissue of the ovary accounted for 8% of ovarian cancers. The excess estrogen produced by Sex cord stromal ovarian tumor can lead to certain symptoms, such as adult granulosa cell tumours and thecomas, postmenopausal bleeding, menorrhagia, amenorrhea, endometrial hyperplasia, etc. The cancer tend to develop in older age group.

D. Secondary cancer

Due to distant spread from other cancer to the ovaries.

E. Etc.


Types of food to prevent and treat  Ovarian cancer
1. Grapes and berries
Myricetin is a flavonol, belong to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, etc.. In the research of inverse associations with certain flavonoids or flavonoid subclasses (myricetin, kaempferol, quercetin, luteolin, and apigenin) and ovarian cancer risk, found that In analyses of each individual flavonoid, only intake of apigenin was associated with a borderline significant decrease in risk (RR, highest vs. lowest quintile = 0.79, 95% CI = 0.59-1.06; p-trend = 0.26), and this association was significant after adjustment for intake of the other 4 individual flavonoids (comparable RR = 0.72, 95% CI = 0.53-0.98; p-trend = 0.09), according to "Flavonoid intake and ovarian cancer risk in a population-based case-control study" by Gates MA, Vitonis AF, Tworoger SS, Rosner B, Titus-Ernstoff L, Hankinson SE, Cramer DW.(1)

2. Green tea
a. In prospective cohort study to investigate whether tea consumption can enhance the survival of patients with epithelial ovarian cancer conducted in Hangzhou, China, found that Compared to non-drinkers, the adjusted hazard ratios were 0.55 (95% CI = 0.34-0.90) for tea-drinkers, 0.43 (95% CI = 0.20-0.92) for consuming at least 1 cup of green tea/day, 0.44 (95% CI = 0.22-0.90) for brewing 1 batch or more of green tea/day, 0.40 (95% CI = 0.18-0.90) for consuming more than 500 g of dried tea leaves/year, and 0.38 (95% CI = 0.15-0.97) for consuming at least 2 g of dried tea leaves/batch. The corresponding dose-response relationships were significant (p < 0.05)(2).
b. Other suggested that studies on the health benefits of drinking tea, particularly green tea, are finding exciting results, particularly in cancer research. Modern studies in both Asia and the West have provided encouraging results indicating that drinking green tea contributes to fighting many different kinds of cancers including stomach, oesophageal, ovarian and colon(3).

3. Turmeric
a. In the study to analyze  the impact of sphingosine kinase-1 (SphK-1) inhibition on ceramides production, and evaluated SphK1 inhibitor II (SKI-II) as a potential curcumin chemo-sensitizer in ovarian cancer cells, found that inhibition of SphK1 by SKI-II or by RNA interference (RNAi) knockdown dramatically enhanced curcumin-induced apoptosis and growth inhibition in ovarian cancer cells. SKI-II facilitated curcumin-induced ceramides production, p38 activation and Akt inhibition. Inhibition of p38 by the pharmacological inhibitor (SB 203580), a dominant-negative expression vector, or by RNAi diminished curcumin and SKI-II co-administration-induced ovarian cancer cell apoptosis, and, to restore Akt activation by introducing a constitutively active Akt (CA-Akt), or to inhibit ceramides production by fumonisin B1 also inhibited curcumin plus SKI-II co-administration-induced in vitro anti-ovarian cancer effect(4).

b. Others found that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3). In addition, p53 knockdown or p53 inhibition did not diminish curcumin killing of HEY cells, confirming p53-independent cytotoxicity. Curcumin also killed OVCA429, and SKOV3 cells grown as multicellular spheroids(5).

4. Etc.

Made From Fresh Fruits And Vegetable Recipes 
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html

For more health articles, please visit http://medicaladvisorjournals.blogspot.ca   

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19117058
(2) http://www.ncbi.nlm.nih.gov/pubmed/15382073
(3) http://www.ncbi.nlm.nih.gov/pubmed/22039897
(4) http://www.ncbi.nlm.nih.gov/pubmed/22594559 

(Phytochemicals in) Foods to Prevent and Treat Cancers - Thyroid Cancer

Thyroid is one of the largest endocrine glands found in the neck, below the Adam's Apple with the function of regulating the body use of energy, make of proteins by producing its hormones as a result of the stimulation of thyroid-stimulating hormone (TSH) produced by the anterior pituitary.

Thyroid cancer is defined as condition in which the cells in the thyroid gland have become cancerous.

Types of thyroid cancer
The most common types of thyroid cancer include
1. Papillary thyroid cancer
Papillary thyroid cancer, the most common type of thyroid cancer, makes up about 80 percent of all thyroid cancers. The cancer tends to develop in the women age group between 30-40 years of age and grow slowly. Papillary thyroid cancer can be cure if diagnosed early.
2. Follicular thyroid cancer
Follicular thyroid cancer, the second most common thyroid cancer, makes up about 15 percent of all case. It is a low grow cancer with peak onset ages 40 through 60. Follicular thyroid cancer can be treat successful, if diagnosed early.
3. Medullary thyroid cancer
Medullary thyroid cancer, third most common thyroid cance makes up about 3 percent of all cases, arise from thyroid hormone producing cells with abnormally high levels of calcitonin. Medullary thyroid cancer tends to grow slowly but it can spread to distant parts of the body, if not treated early.
4. Anaplastic thyroid cancer
Anaplastic thyroid cancer the rare case of thyroid cancer, makes up less than 2 percent of all cases. The cancer cells tend to grow and spread very quickly. Anaplastic thyroid cancer is deadly, with only 10% of alive rate, 3 years after it is diagnosed.

Types of food to prevent and treat thyroid cancer
1. Legumes, soy and peanut
Daidzein is a phytochemical in the Isoflavones, belonging to the group of Flavonoids (polyphenols), found abundantly in food of the family of legumes, soy, peanut, etc..In the study to explore whether or not human thyroid cancer cell growth can be curbed by a novel isoflavone derivative generated in our laboratory, the N-t-Boc-hexylenediamine derivative of 7-(O)-carboxymethyl daidzein (cD-tboc), showed that when nude mice carrying ARO thyroid xenografts were treated with cD-tboc, tumor volume decreased significantly, and no apparent toxicity was observed. These results suggest that cD-tboc may be a promising agent for therapy of thyroid carcinoma either alone or in combination with existing cytotoxic drugs(1).

2. Soybean
In the study to observe that an acidic methanolic extract of soybeans contains compounds that inhibit thyroid peroxidase-(TPO) catalyzed reactions essential to thyroid hormone synthesis, showed that In the presence of iodide ion, genistein and daidzein blocked TPO-catalyzed tyrosine iodination by acting as alternate substrates, yielding mono-, di-, and triiodoisoflavones. Genistein also inhibited thyroxine synthesis using iodinated casein or human goiter thyroglobulin as substrates for the coupling reaction(2).

3. Green tea
Epigallocatechin-3-gallate (EGCG), a major catechin in green tea, was shown to possess remarkable therapeutic potential against various types of human cancer cells in in vitro and in vivo models.  In the study to investigate the effect of EGCG on the proliferation and apoptosis of ARO cells--human ATC cells, showed that EGCG treatment inhibited the growth of ARO cells in a dose-dependent manner. Furthermore, EGCG suppressed phosphorylation of EGFR, ERK1/2, JNK, and p38. These changes were associated with increased p21 and reduced cyclin B1/CDK1 expression. In addition, EGCG treatment increased the accumulation of sub-G1 cell, activated caspase-3 and cleaved PARP(3).

4. Etc.

Made From Fresh Fruits And Vegetable Recipes 
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html

For more health articles, please visit http://medicaladvisorjournals.blogspot.ca 


Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21600982
(2) http://www.ncbi.nlm.nih.gov/pubmed/9464451 
(3) http://www.ncbi.nlm.nih.gov/pubmed/21725973 

(Phytochemicals in) Foods to Prevent and Treat Cancers - Testicular Cancer

Testicular Cancer is a cancer arises in the testicles (testes), which are located inside the scrotum, part of male reproductive system, responding to the production and reproduction of male sex hormones and sperm. It tends to develop in the age groups of twenties and thirties.

Types of testicular cancer
1. Seminomas (Cancers of sperm producing cells)
Seminomas are originated from the sperm producing cells and accounted for 40% of all cases, seminomas tend to slower growing cancer, but it can spread to the lymph nodes in a quarter of patients. In most cases, it can be cured by radiotherapy and chemotherapy.

2. Non-seminomas (Cancers of embryonal type of cells)
Non-seminomas are originated from the embryonal type of cells and accounted for 40% of all cases of testicular cancer. Non-seminomas are aggressive and tend to spread quickly, including a. Embryonal carcinomas
Embryonla carcinomas are very aggressive tumors and tend to grow quickly and spread to distant parts of the body including the lungs and liver.

b. Teratoma carcinomas
Teratoma carcinomas tend to develop in young boys more then adult men and are generally benign and rarely spread to nearby tissues and distant parts of the body.

c. Yolk-sac tumors
Yolk-sac tumors is a rare type of testicular cancer
c.1. If it affects in children, it can be treated successfully in most cases
c.2. if it affects adult men, it can be treated by chemotherapy, even if they have spread.

d. Choriocarcinomas
Choriocarcinomas, a rare type of testicular cancer, affects mostly younger men and responds poorly to radiation and chemotherapy and carries high mortality rate.

Types of food to prevent and treat testicle cancer
1. Nutrient mixture (NM)
In the study to investigate the inhibitory effects of a nutrient mixture (NM)
a. Lysine (Beans and other legumes)
b. Proline (Gelatin)
c. Arginine (Spinach, Lentils and Whole Grains)
d. Ascorbic acid (Circuit fruit)
e. Green tea
on human testicular cancer cell line NT 2/DT matrigel invasion and MMP activity, showed that The nutrient mixture showed no significant effect on testis cancer cell growth. Zymography demonstrated secretion of MMP-2 by untreated human testis cancer cells and MMP-9 with PMA induction. NM inhibited secretion of both MMPs in a dose-dependent fashion with virtual total inhibition of MMP-9 at 100 microg/mL. Invasion of human testis cancer cells through Matrigel was reduced by 84% at 50 microg/mL and at 100 microg/mL (p = 0.004). NM significantly inhibited MMP secretion and matrix invasion in testicular cancer cells without toxic effect, indicating potential as an anticancer agent(1)

2. Etc.



Made From Fresh Fruits And Vegetable Recipes 
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html

For more health articles, please visit http://medicaladvisorjournals.blogspot.ca   

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/17848742

(Phytochemicals in) Foods to Prevent and Treat Cancers - Stomach Cancer/Gastric Cancer

Stomach located between the esophagus and the small intestine, is a muscular, hollow and an important organ of the digestive tract.

Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells ofthe inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

Types of stomach cancer
1. Adenocarcinoma
If cancer arises from the glands in the mucosa
a. Superficial spreading
It is an early stage of the cancer and tend to be less aggressive or ulcer
b. Polyloid
Cancer grows in pattern like a polyp and is less aggressive.
c. Infiltrating
If cancer grows in infiltrating pattern into the stomach wall and more aggressive.
d. Linitis plastica
Cancer grows diffusivity throughout the whole wall of stomach

2. Lymphomas
Cancer of the lymphocytes originated from the stomach and behave much like lyphomas of the other parts of the body but adenocarcinoma

3. Sarcomas
Cancer originated from the connected tissue of the stomach behave much like sarcomas of the other parts of the body but adenocarcinoma.

Types of food to prevent and treat Stomach Cancer/Gastric Cancer
1.  Broccoli and broccoli sprout
Some reserachers suggested that sulforaphane [(-)-1-isothiocyanato-(4R)-(methylsulfinyl)butane], an isothiocyanate abundant as its glucosinolate precursor in certain varieties of broccoli and broccoli sprouts, is a potent bacteriostatic agent against 3 reference strains and 45 clinical isolates of H. pylori [minimal inhibitory concentration (MIC) for 90% of the strains is <or=4 microg/ml], irrespective of their resistance to conventional antibiotics. Further, brief exposure to sulforaphane was bactericidal, and eliminated intracellular H. pylori from a human epithelial cell line (HEp-2). In complementary experiments, sulforaphane blocked benzo[a]pyrene-evoked forestomach tumors in ICR mice. This protection resulted from induction of phase 2 detoxication and antioxidant enzymes, and was abrogated in mice lacking the nrf2 gene, which regulates phase 2 enzymes. Thus, the dual actions of sulforaphane in inhibiting Helicobacter infections and blocking gastric tumor formation offer hope that these mechanisms might function synergistically to provide diet-based protection against gastric cancer in humans(1).

2. Turmeric
Curcumin, a phytochemical compound found in Turmeric has exerted the inhibitory effect against Gastric Cancer. Dr. Sintara K and scientist at the  Chulalongkorn University, indicated that curcumin treatments for 3 and 20 weeks reduced the cancer incidence resulting in a decrease of phospho-IκBα expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin treatment for 20 weeks also decreased 8-OHdG expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin can attenuate cancer via a reduction of phospho-IκBα and 8-OHdG expressions, which may play a promising role in gastric carcinogenesis(2).

3. Legumes and soy
Genistein is a phytochemical in the Isoflavones, belonging to the group of Flavonoids (polyphenols), found abundantly in food of the family of legumes, soy, etc. In the study to determinewhether the effect of genistein is mediated via suppression of cyclo-oxygenase (COX)-2 protein, and elucidated the mechanism of action of this effect in the human gastric cancer cell line BGC-823, showed that Genistein treatment inhibited cell proliferation and induced apoptosis in a dose- and time-dependent manner; Western blotting analysis indicated a significant dose-dependent decrease in COX-2 protein levels. Genistein treatment exerted a significant inhibitory effect on activation of the transcription factor nuclear factor κB (NF-κB). Additionally, the NF-κB inhibitor pyrrolidine dithiocarbamate caused a reduction in COX-2 protein levels and NF-κB activation, similar to the effect of genistein(3).

4. Apple and Chamomille Tea
Quercetin is a member of flavonoids, found in apple and Chamomille Tea. It is also one of antioxidants with property of protecting our body in fighting against forming of free radicals cause of mutation of cells`DNA. Dr. Qin Y and scientists at the Wuhan University of Science and Technology,
indicated that Quercetin could inhibit the Proliferation of MGC-803 cells. It is probably relevant to the down-regulation the expressions of Leptin and Leptin receptor protein, Leptin mRNA and Leptin receptor mRNA by JAK-STAT pathway(4).

5. Etc.

Made From Fresh Fruits And Vegetable Recipes 
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html

For more health articles, please visit http://medicaladvisorjournals.blogspot.ca   

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/12032331 
(2) http://www.ncbi.nlm.nih.gov/pubmed/22690125
(3) http://www.ncbi.nlm.nih.gov/pubmed/22289529

(Phytochemicals in) Foods to Prevent and Treat Cancers - Skin Cancer (Excluding Melanoma)

Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and often detected at an early stage.

Types of skin cancers
The three most common skin cancers are
1. Basal cell cancer
It is the most common type of skin cancer as a result of abnormal growth of the cells in the lowest layer of the epidermis. The cancer rarely spread and kill but can cause significant destruction and disfigurement to the affected skin area and accounted for more than 90% of all skin cancer in the U.S.
2. Squamous cell cancer
It arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.
3. Melanoma
Melanoma is a kind of skin cancer but less common to other skin cancer as a result of malignancy of melanocytes, which are the cell produced dark pigment for your skin. see Melanoma Skin Cancer (Malignant Melanoma) 

Types of food to prevent and treat skin cancer
1. Green tea
In the  investigations and mechanistic studies that define and support the photoprotective efficacy of green tea polyphenols (GTPs) against UV carcinogenesis, showed that oral administration of GTPs in drinking water or the topical application of EGCG prevents UVB-induced skin tumor development in mice, and this prevention is mediated through: (a) the induction of immunoregulatory cytokine interleukin (IL) 12; (b) IL-12-dependent DNA repair following nucleotide excision repair mechanism; (c) the inhibition of UV-induced immunosuppression through IL-12-dependent DNA repair; (d) the inhibition of angiogenic factors; and (e) the stimulation of cytotoxic T cells in a tumor microenvironment(1).

2. Turmeric,
In the study of  curcumin loaded chitin nanogels (CCNGs) were developed using biocompatible and biodegradable chitin with an anticancer curcumin drug. Chitin, as well as curcumin, is insoluble in water,
indicated that The CCNGs showed a 4-fold increase in steady state transdermal flux of curcumin as compared to that of control curcumin solution. The histopathology studies of the porcine skin samples treated with the prepared materials showed loosening of the horny layer of the epidermis, facilitating penetration with no observed signs of inflammation. These results suggest that the formulated CCNGs offer specific advantage for the treatment of melanoma, the most common and serious type of skin cancer, by effective transdermal penetration(2).

3. Tea, Grapes and berries
Myricetin is a flavonol, belong to the flavonoid in Flavonoids (polyphenols), found in many tea grapes, berries, fruits, etc. In the affirmation of myricetin, a flavonol, found to inhibit UVB-induced angiogenesis by targeting PI3-K in an SKH-1 hairless mouse skin tumorigenesis model. Raf kinase is a critical target for myricetin in inhibiting the UVB-induced formation of wrinkles and suppression of type I procollagen and collagen levels in mouse skin, according to "Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis" by Kang NJ, Jung SK, Lee KW, Lee HJ.(3)

4. Grapes and red wine
in the study to evaluate the chemopreventive effects of resveratrol against UVB radiation-mediated skin tumorigenesis in the SKH-1 hairless mouse model, suggests that resveratrol enhanced apoptosis in UVB-exposure-mediated skin tumors. Our study, for the first time, demonstrated that 1) resveratrol imparts strong chemopreventive effects against UVB exposure-mediated skin carcinogenesis (relevant to human skin cancers), and 2) the chemopreventive effects of resveratrol may, at least in part, be mediated via modulations in Survivin and other associated events. On the basis of our work, it is conceivable to design resveratrol-containing emollient or patch, as well as sunscreen and skin-care products for prevention of skin cancer and other conditions, which are believed to be caused by UV radiation(4).


Made From Fresh Fruits And Vegetable Recipes 
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html

For more health articles, please visit http://medicaladvisorjournals.blogspot.ca   

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/17049833
(2) http://www.ncbi.nlm.nih.gov/pubmed/22080352 
(3) http://www.ncbi.nlm.nih.gov/pubmed/21793847
(4) http://www.ncbi.nlm.nih.gov/pubmed/22080352 

(Phytochemicals in) Foods to Prevent and Treat Cancers - Prostate Cancer

Prostate warped around the around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of semen that carries sperm.

Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Types of food to prevent and treat prostate cancers
1. Tomato
In the study of `Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis.`by Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH, Stampfer MJ. (Source from Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA. pgann@nwu.edu), researchers found that the ORs for all prostate cancers declined slightly with increasing quintile of plasma lycopene (5th quintile OR = 0.75, 95% CI = 0.54-1.06; P, trend = 0.12); there was a stronger inverse association for aggressive prostate cancers (5th quintile OR = 0.56, 95% CI = 0.34-0.91; P, trend = 0.05). In the placebo group, plasma lycopene was very strongly related to lower prostate cancer risk (5th quintile OR = 0.40; P, trend = 0.006 for aggressive cancer), whereas there was no evidence for a trend among those assigned to beta-carotene supplements and concluded that These data provide further evidence that increased consumption of tomato products and other lycopene-containing foods might reduce the occurrence or progression of prostate cancer(1).

2. Grapes and berries
Myricetin, a flavonol, belong to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, fruits, etc has been used as antioxidant to lower cholesterol, treat certain types of cancer, etc.
In the selection of several potential uPA inhibitors (antipain, leupeptin, folic acid, rosmarinic acid, lavendustin A, fisetin, myricetin, tolfenamic acid) and examination of theirs effects in prostate cancer found that a proper diet rich in uPA-inhibiting nutraceuticals might support the prevention of prostrate cancer and be a supportive tool in prostate cancer treatment, according to "Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment" by Jankun J, Selman SH, Aniola J, Skrzypczak-Jankun E.(2)

3. Green and black tea
Tea polyphenols have been extensively studied in cell culture and animal models where they inhibited tumor onset and progression. "In vivo animal, and clinical intervention studies examine the effects of extracts of GT or purified (-)-epigallocatechin-3-gallate (EGCG) on prostate carcinogenesis. These studies provide strong evidence supporting a chemopreventive effect of GT, but results from epidemiological studies of GT consumption are mixed. While the evidence for a chemopreventive effect of BT is much weaker than the body of evidence with regard to GT, there are several animal BT intervention studies demonstrating inhibition of CaP growth" said Dr. Henning SM, and the research team at the University of California(3)

4. Soy milk
In the study to examine of a prospective study with 225 incident cases of prostate cancer in 12,395 California Seventh-Day Adventist men who in 1976 stated how often they drank soy milk.
suggests that men with high consumption of soy milk are at reduced risk of prostate cancer. Possible associations between soy bean products, isoflavones and prostate cancer risk should be further investigated(4).

5. Etc.

Made From Fresh Fruits And Vegetable Recipes 
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html

For more health articles, please visit http://medicaladvisorjournals.blogspot.ca   

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/10096552
(2) http://www.ncbi.nlm.nih.gov/pubmed/16820913 
(3) http://www.ncbi.nlm.nih.gov/pubmed/21538852
(4) http://www.ncbi.nlm.nih.gov/pubmed/10189040 

(Phytochemicals in) Foods to Prevent and Treat Cancers - Pancreatic Cancer (Exocrine Cancers)

Pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, pancreas helps to break down carbohydrates, proteins, and lipids. Traditional Chinese medicine view pancreas as a vital organ in responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.

Cancer of pancreas or pancreatic cancer is defined as condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably. Most pancreatic cancers start in the ducts (exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue accounts for over 75 - 90% of all cases of exocrine cancers.

Types of food to prevent and treat pancreatic cancer 
1. Pomegranate
Pomegranate extract (PE) is a standardized whole-fruit extract of pomegranate, a fruit with known anticancer properties, Dr. Nair V, and the research team at the University of Texas at Austin, in the study ofPomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells, showed that PE treatment induced cell cycle arrest and inhibited cell proliferation in PANC-1 cells. PE treatment increased the proportion of cells lacking CD44 and CD24 expression, which are associated with increased tumor-initiating ability, demonstrating that PE altered cell phenotype. PE was more effective in inhibiting the proliferation of PANC-1 cells than the clinically used dose of paclitaxel. Similar results were obtained in the AsPC-1 cell line. Individual pomegranate phytochemicals were only modestly effective in inhibiting cell proliferation(1).

2. Curcumin, raspberry and neem leaf
the study of Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells showed that CUR, NLE, and RSE may serve as effective "deliverables" to potentiate RT in PC cure and further throw light that these phytochemicals-induced cell killing may involve selective regulation of RT-induced NF-κB(2).

3. Tomato
Lycotene is a phytochemical compound and bright red pigment belonging to group of carotene in the family of carotenoids found mostly in tomatoes. In the study to investigate the possible association between dietary carotenoids and pancreatic cancer risk. A case-control study of 462 histologically confirmed pancreatic cancer cases and 4721 population-based controls in 8 Canadian provinces took place between 1994 and 1997, showed that After adjustment for age, province, BMI, smoking, educational attainment, dietary folate, and total energy intake, lycopene, provided mainly by tomatoes, was associated with a 31% reduction in pancreatic cancer risk among men [odds ratio (OR) = 0.69; 95% CI: 0.46-0.96; P = 0.026 for trend] when comparing the highest and lowest quartiles of intake. Both beta-carotene (OR = 0.57; 95% CI: 0.32-0.99; P = 0.016 for trend) and total carotenoids (OR = 0.58; 95% CI: 0.34-1.00; P = 0.02 for trend) were associated with a significantly reduced risk among those who never smoked. The results of this study suggest that a diet rich in tomatoes and tomato-based products with high lycopene content may help reduce pancreatic cancer risk(3).

4.  Grapes and berries
Myricetin, a flavonol, belong to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, etc. has been used as antioxidant to lower cholesterol, treat certain types of cancer, etc. In the observation of the flavonoid myricetin and its effect on metastatic pancreatic cancer cell lines, found that myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer, according to the study of "Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway" by Phillips PA, Sangwan V, Borja-Cacho D, Dudeja V, Vickers SM, Saluja AK.(4)

5. Etc.



Made From Fresh Fruits And Vegetable Recipes 
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html

For more health articles, please visit http://medicaladvisorjournals.blogspot.ca   

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21868510
(2) http://www.ncbi.nlm.nih.gov/pubmed/21697760 
(2) http://www.ncbi.nlm.nih.gov/pubmed/15735099
(4) ) http://www.ncbi.nlm.nih.gov/pubmed/21676539