Endomatrial Cancer
Endometrium is the inner lining of the mammalian
uterus and very susceptible hormone change, particular to menstrual
cycle. Endometrial cancer is a late adulthood cancer defined as a
condition of which the cells of the endometrial lining of uterus have
growth uncontrollable or become cancerous as a result of the alternation
of cells DNA. It's the fourth most common cancer among women overall,
after breast cancer, lung cancer, and bowel cancer.
II. Types of foods to prevent and treat endometrial cancer
1. Legumes
Genistein, a phytochemical in the Isoflavones, found abundantly in
Legumes, has exerted protective effects against endometrial cancer. Dr.
Sampey BP, and the research team at the University of North Carolina at
Chapel Hill showed that nutritionally relevant concentrations (nM) of
genistein inhibit the proliferative effects of estrogen on endometrial
adenocarcinoma cells presumably through activation of stromal cell ERĪ².
We believe that sub-micromolar concentrations of genistein may
represent a novel adjuvant for endometrial cancer treatment and prevention(1).
2. Soy food and tea
In the study to investigate the interactive effect of polymorphisms in the sex hormone-binding globulin (SHBG) gene with soy isoflavones, tea consumption, and dietary fiber on endometrial cancer risk in a population-based, case-control study of 1,199 endometrial cancer patients and 1,212 controls, found that the Asp(327)Asn (rs6259) polymorphism was associated with decreased risk of endometrial cancer,
particularly among postmenopausal women (OR = 0.79, 95% CI =
0.62-1.00). This single nucleotide polymorphism (SNP) modified
associations of soy isoflavones and tea consumption but not fiber intake with endometrial cancer, with the inverse association of soy
intake and tea consumption being more evident for those with the
Asp/Asp genotype of the SHBG gene at Asp(327)Asn (rs6259), particularly
premenopausal women (P(interaction) = 0.06 and 0.02, respectively, for soy isoflavones and tea intake)(2).
3. Cruciferous vegetables
Indole-3-carbinol (I3C) found a abundantly in Cruciferous vegetables has
exerted protective effect that cause endomatrial cancer cells
apoptosis. In the study to examine the possibility that induction of
growth arrest in response to
DNA damage (GADD) in genes by diindolylmethane (DIM), which is the
acid-catalyzed condensation product of I3C, promotes metabolically
stressed cancer cells to undergo apoptosis, indicated that a synergistic effect of I3C and genistein for induction of GADD
expression, thus increasing apoptosis, and for decrease of expression
driven by ER-alpha. Because of the synergistic effect of I3C and
genistein, the potential exists for prophylactic or therapeutic efficacy
of lower concentrations of each phytochemical when used in combination(3).
4. Legume, soy, tofu, and isoflavone intake
Other researchers suggested that a reduced risk of endometrial cancer
was associated with total isoflavone intake (highest vs lowest
quintile, ≥7.82 vs <1.59 mg per 1000 kcal/d, RR = 0.66, 95% CI = 0.47
to 0.91), daidzein intake (highest vs lowest quintile, ≥3.54 vs
<0.70 mg per 1000 kcal/d, RR = 0.64, 95% CI = 0.46 to 0.90), and
genistein intake (highest vs lowest quintile, ≥3.40 vs <0.69 mg per
1000 kcal/d, RR = 0.66, 95% CI = 0.47 to 0.91). No statistically
significant association with endometrial cancer risk was observed for increasing intake of legumes, soy, tofu, or glycitein. Truncated age-adjusted incidence rates of endometrial cancer
for the highest vs lowest quintile of total isoflavone intake were 55
vs 107 per 100 000 women per year, respectively. The partial population
attributable risk percent for total isoflavone intake lower than the
highest quintile was 26.7% (95% CI = 5.3% to 45.8%)(4).
5. Etc.
Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant
And Healthy Lifestyle
That You Can Find
Easily At The Comfort Of Your Kitchen.
For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html
For more health articles, please visit http://medicaladvisorjournals.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21281625
(2) http://www.ncbi.nlm.nih.gov/pubmed/19005973
(3) http://www.ncbi.nlm.nih.gov/pubmed/12840226
Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant
And Healthy Lifestyle
That You Can Find
Easily At The Comfort Of Your Kitchen.
For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html
For more health articles, please visit http://medicaladvisorjournals.blogspot.ca
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