I. Hodgkin's Lymphoma
Hodgkin's
Lymphoma, a type of lymphoma is also known as Hodgkin's Disease started
from the lymph nodes in the chest, armpits and neck. It was named under
Thomas Hodgkin, for first to describe the abnormalities of the lymph
system in 1832. Hodgkin's lyphoma, is invasive and tends to spread
orderly from one lymph node group to another. It is not a common disease
with approximately 800 and 7000 of new cases reported every year in
Canada and US accordingly and mostly occurs to young adults and after
the age of 45.
II. Types of Hodgkin's lymphoma
1. Nodular sclerosis Hodgkin's Lymphoma's (NSHD)
It is the most common type of Hodgkin's lymphoma, accounted for 60% to 80% of all cases originated from the lymph nodes of the chest, including the upper diaphragm and abdominal muscles that control breathing just under the lung.
2. Mixed cellularity Hodgkin's lymphoma (MCHD)
It
is another type of Hodgkin's lymphma, accounted for 15 - 30% of all
cases and tends to affect the lymph nodes of the abdomen, the neck and
armpits and men than women with all ages.
3. Lymphocyte depletion Hodgkin's lymphoma (LDHD)
It
is a rare type of Hodgkin's lymphoma accounted less than 1% of all
cases and occurred more often in the undeveloped world. Most of the time
it is detected without enlarged lymph nodes in the neck, armpits or
groin. The disease is classified to 2 subtypes
a. Nodular lymphocyte predominant Hodgkin's lymphoma (nLPHD)
b. Diffuse lymphocyte predominant Hodgkin's lymphoma (dLPHD)
4. Lymphocyte-rich classic Hodgkin's lymphoma (cLRHD)
It
is also another rare type of Hodgkin's lymphoma, accounted for
approximate for 5% of all cases and tends to occur in the age group of
45+ years of age and more in men than women. It is most common to be
detected with an enlargement of lymph nodes in the neck, chest or
armpits, other lymph nodes and organs.
5. Etc.
III. Types of Food to prevent and treat Hodgkin's Lymphoma/Hodgkin's Disease
1. Green Tea
Flavan-3-ols [(-)-epicatechin (EC) and (+)-catechin (CT)] and a B dimeric procyanidin (DP-B), a group of phytochemical found abundantly in green tea has exerted the protective effect against Hodgkin's Lymphoma. Dr. Mackenzie GG and Dr. Oteiza PI at the University of California Davis indicated that pretreatment with EC, CT, or DP-B decreased PMA-induced NF-kappaB
binding activity and the transactivation of the NF-kappaB-driven gene
IL-2. EC, CT, and DP-B inhibited, in vitro, NF-kappaB binding to its DNA
consensus sequence, but they had no effect on the binding activity of
CREB or OCT-1. Thus, EC, CT, or DP-B can influence the immune response
by modulating NF-kappaB activation. This modulation can occur at early
(regulation of oxidant levels, IKK activation) as well as late (binding
of NF-kappaB to DNA) stages of the NF-kappaB activation cascade. A model
is presented for possible interactions between DP-B and NF-kappaB
proteins, which could lead to the inhibition of NF-kappaB binding to
kappaB sites(1).
2. Cocoas
Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells, Dr. Mackenzie GG and the team of researchers at the University of California, indicated that EC inhibited NF-kappaB-DNA binding activity in L-428 and KM-H2 cells.
This inhibition was not associated with EC antioxidant activity, with
changes in p65 phosphorylation or NF-kappaB nuclear translocation.
Results suggest that EC acted inhibiting the binding of NF-kappaB to
DNA. The combined treatment with EC and an inhibitor of NF-kappaB
nuclear translocation (SN-50) caused an additive inhibitory effect on
NF-kappaB activation, in the study to investiagte the capacity of EC to inhibit NF-kappaB activation, the
underlying mechanisms and the effects of EC on cell viability in Hodgkin's lymphoma cells(2).
3. Turmeric
Curcumin is a phytochemical
found abundant in turmeric. In acidic solutions (pH <7.4) it turns
yellow, whereas in basic (pH > 8.6) solutions it turns bright red. The phytochemical curcumin induces cell-arrest and apoptosis in association with the
inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells(3).
4. Etc.
Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant
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For the series of Foods to prevent and treat cancers, visit http://foodstopreventandtreatcancers.blogspot.ca/p/phytochemical-in-foods-to-prevent-and.html
For more health articles, please visit http://medicaladvisorjournals.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/17015253
(2) http://www.ncbi.nlm.nih.gov/pubmed/18275936
(3) http://www.ncbi.nlm.nih.gov/pubmed/18386790
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